Cand)Ex clears Systemic Candidiasis, maintains healthy balance of intestinal and vaginal
flora. Candida albicans overgrowth - manifesting as: Gastrointestinal candidiasis, Thrush and Vaginal yeast infections.
60 x 500 mg Capsules
- Maintains healthy balance of intestinal and vaginal flora
- Inhibits formation of Candida biofilm
- Gastrointestinal candidiasis
- Vaginal yeast infections
- Herpes simplex
- Lethargy and fatigue
- Chronic diarrhoea, constipation, bloating and flatulence
- Rectal itching
- Skin eruptions
Start with 1-2 capsules per day. Increase dose by 1 capsule every 2 days until desired results are achieved (most commonly 4-6 per day).
Enzymes: amylase, lipase & protease
Coptis chinensis (rhizome)
Lonicera japonica (stem)
Lysimachia christinae (whole plant)
Reynoutria japonica (root) (contains resveratrol)
Agastache rugosa (whole plant)
Anemone pulsatilla (root)
Handroanthus impetiginosus (stem bark)
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
Candida albicans is normally a harmless yeast present in the gastrointestinal tract and vaginas of warm-blooded animals. A healthy immune system and beneficial bacteria keep Candida under control, but disruption to this internal balance can lead to yeast overgrowth. Hormonal imbalances, antibiotics and oral contraceptives, excessive consumption of sugar and simple carbohydrates, food allergies and sensitivities, stress, or exposure to environmental toxicants can all lower immune defences and contribute to Candida’s transformation from a benign, round yeast into a filament-shaped fungus with long hyphae or “roots” that penetrate intestinal cells in search of food. In an advanced stage, Candida expels waste products into the circulatory system, depressing immunity and leading to numerous ailments that may fall within the syndrome called the Candida Related Complex or Candidiasis (Crook, 1984 & 1987). Candida albicans also can be spread by direct contact during intercourse and through intravenous feedings, dialysis and surgery.
Undecylenic acid is an extremely effective, well-tolerated, broad-spectrum antifungal compound derived from the vacuum distillation of castor bean oil. It works, in part, by inhibiting the ability of Candida to convert to its virulent mycelial phase. Several studies have demonstrated that undecylenic acid is 4-5 times as powerful an antifungal agent as caprylic acid in the same dosage. Calcium undecylenate is a stable calcium complex of undecylenic acid that delivers potent anti-Candida activity with greater stability and a longer effective shelf life (Birdsall, 1987; Li et al., 2008 & Mclain et al., 2000)
Pau d’arco (Tabebuia heptaphylla)
The inner bark of the South American tree Pau d’arco, also known as lapacho or taheebo, has long been used as a folk remedy in the treatment of numerous afflictions. Pau d’ Arco contains phytochemical compounds with antibacterial and antifungal activity. Among these compounds are lapachol and a series of napthoquinones, natural fungicidal's effective against Candida albicans. Lapachol is also antiviral and antiparasitic. Pau d’arco selectively inhibits unfriendly bacteria such as the anaerobic Clostridium difficile and E. coli without affecting beneficial probiotic bacteria (Park, 2005 & Portillo et al., 2001).
Enlyse™ is a blend of powerful all-vegetarian enzymes designed to help prevent overgrowth of Candida. This blend improves the intestinal environment by hydrolysing putrefying food trapped in between the intestinal villi and digesting non-starch polysaccharides that are known to create gas and bloating. Hemicellulases in Enlyse™ help remove the biofilm layer, which surrounds Candida albicans. Removal of the yeast’s protective biofilm facilitates the penetration of the antifungal ingredients calcium undecylenate, berberine and resveratrol directly to the yeast cell (Al-Fattani & Douglas, 2006). Chitosanase in Enlyse™ is a special enzyme that helps break down chitin, which is an important part of the structure of the Candida cell wall. This can be a significant factor in the prevention of overgrowth of this potentially pathogenic yeast (Chattaway et al., 1976).
Berberine is a natural antibiotic and antifungal compound found in the herbs goldenseal, barberry and Oregon grape. It successfully eliminates bacteria, protozoa and fungi and is effective against pathogenic Candida albicans. Berberine suppresses Candida’s ability to make enzymes that it uses to invade tissues, and interrupts the process of chitin synthesis by which Candida constructs its cell walls.10-11 Berberine has also been shown to work synergistically with other antifungal agents (Yordanov et al, 2008 & Park et al., 1999).
Resveratrol and Biotin
Trans-resveratrol demonstrates potent antifungal activity at very low concentrations; it acts to disrupt the formation of the hyphae, or mycelia, which are required for Candida to penetrate the epithelial cells lining the gastrointestinal tract (Jung et al., 2005 & 2007). In vitro, biotin has been shown to prevent the budding yeast form of Candida albicans from “morphing” into its invasive mycelial form (Yamaguchi, 1974).
Study on the Effect of Agastache rugosa (Huo Xiang Zheng qi) Liquid on the Gastrointestinal Tract in Rats
YUAN Ye-rong. Liao Ning Zhong Yi Yao Da Xue Xue Bao. 2007; 9(5): 177-178.
Objective: To study the effect of Huo Xiang Zheng qi Liquid (HZL) on the gastrointestinal tract in rabbits; Methods: The experiments on the effect of HZL on the movement of rabbits’ isolated duodenum activated by acetylcholine, gastric emptying and intestine propulsion of HZL in rats and the effect of HZL on the gastrin (GAS) in homogenate of serum, sinus ventriculi, jejunum tissues of rats by radioimmunity were carried out. Results: HZL has distinct inhibition effect on the movement of rabbits’ isolated duodenum and promotion effect on gastric emptying, intestine propulsion and gastrin excretion. Conclusion: The study provided an experiment basis on the gastrointestinal tract therapy of HZL in clinic.
Effect of radix pulsatillae alcohol extract on colitis of rats induced by trinitrobenzenesulfonic acid
ZHANG Wen-yuan, LU Lei. Xi Bu Yi Xue. 2009; 21(4): 536-538.
Objective: To investigate the effect of radix pulsatillae alcohol extract on colitis of rats induced by trini-trobenzenesulfonic acid. Methods 28 male rats were randomly divided into radix pulsatillae alcohol extract treated group (group A, n=10), TNBS control group (group B, n=10) and normal control group (group C, n= 8). 0.85 ml enema containing 30 mg TNBS dissolved in 500% ethanol was instilled into the colon of the rats in group A and group B to induce distal colitis. The rats in group A were perfused through colon with radix pulsatillae alcohol extract at the dosage of 2g/ (kg · d) for 1 ml solution for 7 days, whereas the rats in group B and group C were treated with distilled water. The animals were sacrificed at the 8th day of experiment. The disease activity index (DAD and the tissue damages of colonic mucosa were observed. The levels of tumour necrosis factor a (TNf-a) and interleukin-6 (IL-6) in colonic tissue were measured with enzyme-labelled immunosorbent assay (ELISA). The expression of CD4^T cells and CD8^T cells in colonic tissue and spleen was detected with immunohistochemistry. Results Compared with group B, the disease activity index (DAD and histological damages of colonic mucosa in group A were significantly improved, the levels of TNF-a, IL-6 of colonic tissue and CD4^+T lymphocytes in colonic tissue in group A were significantly decrease (P<0.05), and CD8^+T lymphocytes in colonic tissue and spleen in group A were significantly increased (P<0.05). Conclusion The radix pulsatillae alcohol extract demonstrated an anti-inflammatory action on colitis induced by trinitrobenzenesulfonic acid, and its mechanism might be involved in immunoregulating CD4^+ and CD8^+ T lymphocytes and reducing the levels of TNF-a and IL-6 in colonic tissue.
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Chattaway FW, Shenolikar S, O’Reillt J, Barlow AJ. Changes in the cell surface of the dimorphic forms of Candida albicans by treatment with hydrolytic enzymes. J. Gen Microbiol. 1976 Aug; 96(2): 335-47.
Crook WG. The Yeast Connection and the Woman. Professional Books. Jackson, TN. 1987.
Crook WG. The Yeast Connection, A Medical Breakthrough. 2nd Addition. Professional Books. Jackson, TN, 1984.
Jung HJ, Hwang IA, Sung WS, Kang H, Kang BS, Seu YB, Lee DG. Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res. 2005 May;28(5):557-60.
Jung HJ, Seu YB, Lee DG. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug; 17(8): 1324-9.
Li XC, Jacob MR, Khan SI, Ashfaq MK, Babu KS, Agarwal AK, Elsohly HN, Manly SP, Clark AM. Potent in vitro antifungal activities of naturally occurring acetylenic acids. Antimicrob Agents Chemother. 2008. Jul; 52(7): 2442-8. Epub 2008 May 5.
McLain N, Ascanio R, Baker C, Strohaver RA, Dolan JW. Undecylenic acid inhibits morphogenesis of Candida albicans. Antimicrob Agents Chemother. 2000 Oct; 44(10): 2873-5.
Park KS, Kang KC, Kim JH, Adams DJ, Johng TN, Paik YK. Differential inhibitory effects of protoberberines on sterol and chitin biosynthesis in Candida albicans. J Antimicrob Chemother. 1999 May;43(5):667-74.
Park, B. S., et al. Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. J. Agric. Food Chem. 2005 Feb; 23;53(4): 1152-7.
Portillo, A., Vila, R., Freixa, B., Adzet, T. & Cannigueral, S. Antifungal activity of Paraguayan plants used in traditional medicine. J. Ethnopharmacol. 2001; 76(1): 93–8.
Yamaguchi H. Mycelial development and chemical alteration of Candida albicans from biotin insufficiency. Sabouraudia. 1974 Nov;12(3):320–328.
Yordanov M, Dimitrova P, Patkar S, Saso L, Ivanovska N. Inhibition of Candida albicans extracellular enzyme activity by selected natural substances and their application in Candida infection. Can J Microbiol. 2008 Jun;54(6):435-40.\
Yuan Ye-rong. Liao Ning Zhong Yi Yao Da Xue Xue Bao. 2007; 9(5): 177-178.
Zhang Wen-yuan, LU Lei. Xi Bu Yi Xue. 2009; 21(4): 536-538.